From empirical to precision therapy in ICUs: Rethinking antibiotic use after COVID-19

Authors

  • Hossein Azarmina Critical Care Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran https://orcid.org/0000-0002-9882-0618
  • Niloofar Keikhaei Sayad Shirazi Hospital, Department of Internal Medicine, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran https://orcid.org/0000-0002-7292-8639
  • Kamyar Kharazmi Critical Care Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.61882/jcbior.6.3.331

Keywords:

Post-COVID, Critical care , Antibiotic resistance

Abstract

No abstract.

References

1. Abu-Rub LI, Abdelrahman HA, Johar AA, Alhussain HA, Hadi HA, Eltai NO. Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review. Antibiotics (Basel). 2021;10(8):935. DOI: 10.3390/antibiotics10080935 PMID: 34438985

2. Langford BJ, So M, Raybardhan S, Leung V, Westwood D, MacFadden DR, et al. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020;26(12):1622-1629. DOI: 10.1016/j.cmi.2020.07.016 PMID: 32711058

3. Rawson TM, Moore LSP, Zhu N, Ranganathan N, Skolimowska K, Gilchrist M, et al. Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing. Clin Infect Dis. 2020;71(9):2459-2468.

DOI: 10.1093/cid/ciaa530 PMID: 32358954

4. Karakoc HN, Aydin M, Ozcan SN, Olcar Y, Sumlu E, Dindar EK, et al. To prescribe or not: a two-center retrospective observational study of antibiotics usage and outcomes of COVID-19 in Turkey. Sci Rep. 2024;14(1):21031. DOI: 10.1038/s41598-024-72086-8 PMID: 39251674

5. O'Kelly B, Cronin C, Connellan D, Griffin S, Connolly SP, McGrath J, et al. Antibiotic prescribing patterns in patients hospitalized with COVID-19: lessons from the first wave. JAC Antimicrob Resist. 2021;3(2):dlab085.

DOI: 10.1093/jacamr/dlab085 PMID: 34223144

6. Dambroso-Altafini D, Dos Santos Saalfeld SM, de Souza Ferreira de Mattos M, Martinez HV, Shinohara DR, Zarpellon MN, et al. Overuse of empirical antibiotics in a COVID-19 intensive care unit led to the spread of carbapenem-resistant Gram-negative bacteria in a teaching hospital. J Glob Antimicrob Resist. 2022;30:100-102.

DOI: 10.1016/j.jgar.2022.06.006 PMID: 35710060

7. Timbrook TT, Morton JB, McConeghy KW, Caffrey AR, Mylonakis E, LaPlante KL. The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis. Clin Infect Dis. 2017;64(1):15-23.

DOI: 10.1093/cid/ciw649 PMID: 27678085

8. Mojebi A, Wu P, Keeping S, Hale B, Chase JG, Beaubrun A. Clinical impact of rapid molecular diagnostic tests in patients presenting with viral respiratory symptoms: A systematic literature review. PLoS One. 2024;19(6):e0303560.

DOI: 10.1371/journal.pone.0303560 PMID: 38870136

9. Peri AM, Chatfield MD, Ling W, Furuya-Kanamori L, Harris PNA, Paterson DL. Rapid Diagnostic Tests and Antimicrobial Stewardship Programs for the Management of Bloodstream Infection: What Is Their Relative Contribution to Improving Clinical Outcomes? A Systematic Review and Network Meta-analysis. Clin Infect Dis. 2024;79(2):502-515.

DOI: 10.1093/cid/ciae234 PMID: 38676943

10. Messacar K, Parker SK, Todd JK, Dominguez SR. Implementation of Rapid Molecular Infectious Disease Diagnostics: the Role of Diagnostic and Antimicrobial Stewardship. J Clin Microbiol. 2017;55(3):715-723.

DOI: 10.1128/JCM.02264-16 PMID: 28031432

11. Ackermann K, Baker J, Green M, Fullick M, Varinli H, Westbrook J, et al. Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Adult Inpatients: Scoping Review. J Med Internet Res. 2022;24(2):e31083. DOI: 10.2196/31083 PMID: 35195528

12. Duijkers R, Prins HJ, Kross M, Snijders D, van den Berg JWK, Werkman GM, et al. Biomarker guided antibiotic stewardship in community acquired pneumonia: A randomized controlled trial. PLoS One. 2024;19(8):e0307193.

DOI: 10.1371/journal.pone.0307193 PMID: 39163362

13. Wunderink RG, Srinivasan A, Barie PS, Chastre J, Dela Cruz CS, Douglas IS, et al. Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM. Ann Am Thorac Soc. 2020;17(5):531-540.

DOI: 10.1513/AnnalsATS.202003-188ST PMID: 32356696

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Published

2025-09-30

Issue

Section

Letter

How to Cite

From empirical to precision therapy in ICUs: Rethinking antibiotic use after COVID-19. (2025). Journal of Current Biomedical Reports, 6(3), 88-89. https://doi.org/10.61882/jcbior.6.3.331

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