Medical-grade honey as an antimicrobial agent against Helicobacter pylori: A review of current evidence

Shahrzad Asgari, Parastoo Saniee

Abstract


Honey, a natural product of apian biology, has been recognized for its medicinal properties for centuries. The bioactive compounds present in honey, particularly those found in mono-floral varieties, exhibit antimicrobial, anti-inflammatory, and antioxidant activities. These properties have been demonstrated to synergistically interact, allowing honey to effectively combat a range of microorganisms, including multidrug-resistant bacteria. This review focuses on the antimicrobial properties of medical-grade honey, with a specific emphasis on its potential to inhibit the growth and gene expression of Helicobacter pylori, a bacterium responsible for gastric ulcers and gastric cancer.


Keywords


Medical-grade honey; Helicobacter pylori; Antimicrobial properties

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References


Petrovska BB. Historical review of medicinal plants' usage. Pharmacogn Rev. 2012;6(11):1-5. DOI: 10.4103/0973-7847.95849 PMID: 22654398

Eteraf-Oskouei T, Najafi M. Traditional and modern uses of natural honey in human diseases: a review. Iranian J Basic Med Sci. 2013;16(6):731.

Krishnaiah D, Sarbatly R, Nithyanandam R. A review of the antioxidant potential of medicinal plant species. Food and Bioproducts Processing. 2011;89(3):217-33. DOI: 10.1016/j.fbp.2010.04.008

Singh A, Singh S, Mohan Prasad S. Role of Medicinal Plants for Health Perspective: Special Reference to Antioxidant Potential. J Chem Biol Ther. 2016;01(02). DOI: 10.4172/2572-0406.1000106

Sivaraj R, Rahman PK, Rajiv P, Narendhran S, Venckatesh R. Biosynthesis and characterization of Acalypha indica mediated copper oxide nanoparticles and evaluation of its antimicrobial and anticancer activity. Spectrochim Acta A Mol Biomol Spectrosc. 2014;129:255-8. DOI: 10.1016/j.saa.2014.03.027 PMID: 24747845

Payyappallimana U. Role of traditional medicine in primary health care: an overview of perspectives and challenging. 横浜国際社会科学研究= Yokohama J Social Sci. 2010;14(6):57-77.

Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A. Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview. Medicines (Basel). 2018;5(3). DOI: 10.3390/medicines5030093 PMID: 30149600

Sun W, Shahrajabian MH. Therapeutic Potential of Phenolic Compounds in Medicinal Plants-Natural Health Products for Human Health. Molecules. 2023;28(4). DOI: 10.3390/molecules28041845 PMID: 36838831

Huang WY, Cai YZ, Zhang Y. Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer. 2010;62(1):1-20. DOI: 10.1080/01635580903191585 PMID: 20043255

Raina H, Soni G, Jauhari N, Sharma N, Bharadvaja N. Phytochemical importance of medicinal plants as potential sources of anticancer agents. Turkish J Botany. 2014;38:1027-35. DOI: 10.3906/bot-1405-93

Gullett NP, Ruhul Amin AR, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR, et al. Cancer prevention with natural compounds. Semin Oncol. 2010;37(3):258-81. DOI: 10.1053/j.seminoncol.2010.06.014 PMID: 20709209

Pattamayutanon P, Angeli S, Thakeow P, Abraham J, Disayathanoowat T, Chantawannakul P. Biomedical Activity and Related Volatile Compounds of Thai Honeys from 3 Different Honeybee Species. J Food Sci. 2015;80(10):M2228-40. DOI: 10.1111/1750-3841.12993 PMID: 26317173

Bobis O, Moise AR, Ballesteros I, Reyes ES, Duran SS, Sanchez-Sanchez J, et al. Eucalyptus honey: Quality parameters, chemical composition and health-promoting properties. Food Chem. 2020;325:126870. DOI: 10.1016/j.foodchem.2020.126870 PMID: 32387927

Al-Jabri AA. Honey, milk and antibiotics. African J Biotech. 2005;4(13).

Hermanns R, Mateescu C, Thrasyvoulou A, Tananaki C, Wagener FA, Cremers NA. Defining the standards for medical grade honey. J Apicultural Res. 2020;59(2):125-35.

Molan PC. The Antibacterial Activity of Honey: 1. The nature of the antibacterial activity. Bee World. 2015;73(1):5-28. DOI: 10.1080/0005772x.1992.11099109

El Sohaimy SA, Masry SHD, Shehata MG. Physicochemical characteristics of honey from different origins. Annals of Agricultural Sci. 2015;60(2):279-87. DOI: 10.1016/j.aoas.2015.10.015

Cianciosi D, Forbes-Hernandez TY, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna PP, et al. Phenolic Compounds in Honey and Their Associated Health Benefits: A Review. Molecules. 2018;23(9). DOI: 10.3390/molecules23092322 PMID: 30208664

Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine. 2003;21(5):242-7. DOI: 10.1016/s1043-4666(03)00092-9 PMID: 12824009

Tonks AJ, Dudley E, Porter NG, Parton J, Brazier J, Smith EL, et al. A 5.8-kDa component of manuka honey stimulates immune cells via TLR4. J Leukoc Biol. 2007;82(5):1147-55. DOI: 10.1189/jlb.1106683 PMID: 17675558

Tonks A, Cooper RA, Price AJ, Molan PC, Jones KP. Stimulation of TNF-alpha release in monocytes by honey. Cytokine. 2001;14(4):240-2. DOI: 10.1006/cyto.2001.0868 PMID: 11448125

Molan P. Why honey is effective as a medicine: 2. The scientific explanation of its effects. Bee World. 2015;82(1):22-40. DOI: 10.1080/0005772x.2001.11099498

Baltrušaitytė V, Venskutonis PR, Čeksterytė V. Radical scavenging activity of different floral origin honey and beebread phenolic extracts. Food Chemistry. 2007;101(2):502-14. DOI: 10.1016/j.foodchem.2006.02.007

Albaridi NA. Antibacterial Potency of Honey. Int J Microbiol. 2019;2019:2464507. DOI: 10.1155/2019/2464507 PMID: 31281362

Kwakman PH, te Velde AA, de Boer L, Speijer D, Vandenbroucke-Grauls CM, Zaat SA. How honey kills bacteria. FASEB J. 2010;24(7):2576-82. DOI: 10.1096/fj.09-150789 PMID: 20228250

Kaskoniene V, Venskutonis PR. Floral Markers in Honey of Various Botanical and Geographic Origins: A Review. Compr Rev Food Sci Food Saf. 2010;9(6):620-34. DOI: 10.1111/j.1541-4337.2010.00130.x PMID: 33467823

Castro-Vázquez L, Díaz-Maroto MC, de Torres C, Pérez-Coello MS. Effect of geographical origin on the chemical and sensory characteristics of chestnut honeys. Food Research International. 2010;43(10):2335-40. DOI: 10.1016/j.foodres.2010.07.007

Coticchia JM, Sugawa C, Tran VR, Gurrola J, Kowalski E, Carron MA. Presence and density of Helicobacter pylori biofilms in human gastric mucosa in patients with peptic ulcer disease. J Gastrointest Surg. 2006;10(6):883-9. DOI: 10.1016/j.gassur.2005.12.009 PMID: 16769546

Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017;153(2):420-9. DOI: 10.1053/j.gastro.2017.04.022 PMID: 28456631

Robinwarren J. Unidentified Curved Bacilli on Gastric Epithelium in Active Chronic Gastritis. The Lancet. 1983;321(8336):1273-5. DOI: 10.1016/s0140-6736(83)92719-8

Mobley HLT. Urease. Helicobacter pylori: physiology and genetics. 2014:177-91. DOI: 10.1128/9781555818005.ch16

Chu YT, Wang YH, Wu JJ, Lei HY. Invasion and multiplication of Helicobacter pylori in gastric epithelial cells and implications for antibiotic resistance. Infect Immun. 2010;78(10):4157-65. DOI: 10.1128/IAI.00524-10 PMID: 20696835

Holcombe C, Omotara B, Eldridge D, Jones D. H. pylori, the most common bacterial infection in Africa: a random serological study. American J Gastroenterology (Springer Nature). 1992;87(1).

Peek RM, Jr., Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2(1):28-37. DOI: 10.1038/nrc703 PMID: 11902583

Peek RM, Jr., Crabtree JE. Helicobacter infection and gastric neoplasia. J Pathol. 2006;208(2):233-48. DOI: 10.1002/path.1868 PMID: 16362989

Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108. DOI: 10.3322/canjclin.55.2.74 PMID: 15761078

Nelson RG, Rosowsky A. Dicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations. Antimicrobial Agents and Chemotherapy. 2002;46(3):940-. DOI: 10.1128/AAC.46.3.940-940.2002

Saniee P, HosseinI F, Kadkhodaei S, Siavoshi F, Khalili-Saman S. Helicobacter pylori multidrug resistance due to misuse of antibiotics in Iran. Archives of Iranian Med. 2018;21(7):283-8.

Abdel-Latif MM, Abouzied MM. Molecular Mechanisms of Natural Honey Against H. pylori Infection Via Suppression of NF-kappaB and AP-1 Activation in Gastric Epithelial Cells. Arch Med Res. 2016;47(5):340-8. DOI: 10.1016/j.arcmed.2016.09.002 PMID: 27751367

Almasaudi S. The antibacterial activities of honey. Saudi J Biol Sci. 2021;28(4):2188-96. DOI: 10.1016/j.sjbs.2020.10.017 PMID: 33911935

Nzeako BC, Al-Namaani F. The antibacterial activity of honey on helicobacter pylori. Sultan Qaboos Univ Med J. 2006;6(2):71-6. PMID: 21748138

al Somal N, Coley KE, Molan PC, Hancock BM. Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey. J R Soc Med. 1994;87(1):9-12. DOI: 10.1177/014107689408700106 PMID: 8308841

Ndip RN, Takang A, Echakachi CM, Malongue A, Akoachere J, Ndip LM, et al. In-vitro antimicrobial activity of selected honeys on clinical isolates of Helicobacter pylori. African health sciences. 2007;7(4).

Manyi-Loh CE, Clarke AM, Ndip RN. Detection of phytoconstituents in column fractions of n-hexane extract of Goldcrest honey exhibiting anti-Helicobacter pylori activity. Arch Med Res. 2012;43(3):197-204. DOI: 10.1016/j.arcmed.2012.04.006 PMID: 22560982

Chama Z, Zineddine E, Kanoun K, Benabbou A, Benchiha N, Klouche L, et al. The Antibacterial Activity of Three Samples of Natural Honey Collected from Algerian Territory on The Growth of Helicobacter Pylori. Egyptian Academic Journal of Biological Sciences, E Medical Entomology & Parasitology. 2021;13(2):21-34. DOI: 10.21608/eajbse.2021.208188

Adam Q, Annuar F, Alfizah H, Mohd Fahami NA. In vitro Study of Anti-Helicobacter pylori Activity of Honey: A Systematic Review. Sains Malaysiana. 2020;49(2):411-20. DOI: 10.17576/jsm-2020-4902-20

Voidarou CC, Rozos G, Alexopoulos A, Plessas S, Mantzourani I, Stavropoulou E, et al. In Vitro Screening Potential Antibacterial Properties of the Greek Oregano Honey against Clinical Isolates of Helicobacter pylori. Foods. 2021;10(7). DOI: 10.3390/foods10071568 PMID: 34359441

Romero M, Freire J, Pastene E, García A, Aranda M, González C. Propolis polyphenolic compounds affect the viability and structure of Helicobacter pylori in vitro. Revista Brasileira de Farmacognosia. 2019;29(3):325-32. DOI: 10.1016/j.bjp.2019.03.002

Venegas A, Hantar Touma J, Bravo J, Perez-Perez G. Progress in Use of Natural Products and Their Active Components against <i>Helicobacter pylori</i&gt. Advances in Microbiology. 2016;06(14):1091-129. DOI: 10.4236/aim.2016.614101

Cviljević S, Bilić Rajs B, Primorac L, Strelec I, Gal K, Cvijetić Stokanović M, et al. Antibacterial activity OF Chestnut honey (Castanea sativa Mill.) against Helicobacter pylori and correlation to its antioxidant capacity. Hrana u zdravlju i bolesti: znanstveno-stručni časopis za nutricionizam i dijetetiku. 2020;9(2):52-6.

Chauvaux S, Rosso ML, Frangeul L, Lacroix C, Labarre L, Schiavo A, et al. Transcriptome analysis of Yersinia pestis in human plasma: an approach for discovering bacterial genes involved in septicaemic plague. Microbiology (Reading). 2007;153(Pt 9):3112-24. DOI: 10.1099/mic.0.2007/006213-0 PMID: 17768254

Zhang Y, Burkhardt DH, Rouskin S, Li GW, Weissman JS, Gross CA. A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation. Mol Cell. 2018;70(2):274-86 e7. DOI: 10.1016/j.molcel.2018.02.035 PMID: 29628307

Ayala G, Escobedo-Hinojosa WI, de la Cruz-Herrera CF, Romero I. Exploring alternative treatments for Helicobacter pylori infection. World J Gastroenterol. 2014;20(6):1450-69. DOI: 10.3748/wjg.v20.i6.1450 PMID: 24587621

Dinat S, Orchard A, Van Vuuren S. A scoping review of African natural products against gastric ulcers and Helicobacter pylori. J Ethnopharmacol. 2023;301:115698. DOI: 10.1016/j.jep.2022.115698 PMID: 36174808

Gonzalez A, Salillas S, Velazquez-Campoy A, Espinosa Angarica V, Fillat MF, Sancho J, et al. Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA. Sci Rep. 2019;9(1):11294. DOI: 10.1038/s41598-019-47746-9 PMID: 31383920

Gonzalez A, Casado J, Lanas A. Fighting the Antibiotic Crisis: Flavonoids as Promising Antibacterial Drugs Against Helicobacter pylori Infection. Front Cell Infect Microbiol. 2021;11:709749. DOI: 10.3389/fcimb.2021.709749 PMID: 34354964

Matongo F, Nwodo UU. In vitro assessment of Helicobacter pylori ureases inhibition by honey fractions. Arch Med Res. 2014;45(7):540-6. DOI: 10.1016/j.arcmed.2014.09.001 PMID: 25240315

Kim HW, Woo HJ, Yang JY, Kim JB, Kim SH. Hesperetin Inhibits Expression of Virulence Factors and Growth of Helicobacter pylori. Int J Mol Sci. 2021;22(18). DOI: 10.3390/ijms221810035 PMID: 34576198


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