Evaluation of serum alkaline phosphatase and calcium in type 2 diabetes mellitus patients at Lucknow, India

Mohd Danish Khan, Roshan Alam, Haseeb Ahsan, Mohammad Mustufa Khan, Saba Khan


There is an increasing demand and requirement to develop new biomarkers for the early diagnosis and detection of diabetes mellitus (DM). The present study is designed to estimate serum alkaline phosphatase (ALP) and serum calcium levels in type 2 diabetes mellitus (T2DM) patients. The serum alkaline phosphatase and calcium levels were estimated using commercially available kits on a semiautoanalyzer. The fasting blood sugar (FBS) of the subjects was measured by the glucose oxidase-peroxidase (GOD-POD) method using a commercially available kit. The level of ALP was found to be statistically significant in T2DM patients when compared with matched healthy individuals (p <0.001), whereas the association of serum calcium level was found to be non-significant (p = 0.07). Although there is a decrease in serum calcium level in T2DM patients when compared with healthy controls. It is concluded that the management of T2DM and its associated complications may require regular estimation of serum ALP and calcium levels. The estimations may also be significant in the management of osteoporosis in T2DM patients. High utilization of calcium and vitamin D especially from supplements may lower the risk of DM.


Alkaline phosphatase; Diabetes mellitus; Osteoporosis; Serum calcium; T2DM

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