Frequency of using complementary herbal medicines among Helicobacter pylori-infected patients in the North of Iran

Authors

  • Heydar Ali Balou Department of Internal Medicine, School of Medicine, Gastrointestinal and Liver Disease Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran https://orcid.org/0000-0003-2767-370X
  • Hosnieh Kafshdar Jalali Department of Microbiology, Lahijan Branch, Islamic Azad University, Lahijan, Iran
  • Soheil Soltanipour Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Sina Zare Jalise Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  • Kourosh Delpasand Department of Medical Ethics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran https://orcid.org/0000-0001-6842-3374

DOI:

https://doi.org/10.61882/jcbior.5.1.245

Keywords:

Helicobacter pylori, Gastric ulcer, Herbal medicine

Abstract

Helicobacter pylori is a prevalent infection and one of the most critical factors that result in gastric cancer. Besides antibiotic therapy, some plants are suitable as an alternative treatment against H. pylori infection due to their role in protecting the gastric mucosa. This study investigated the frequency of using complementary herbal medicines among H. pylori-infected patients in the North of Iran. This cross-sectional study was conducted on 390 patients with H. pylori infection undergoing treatment in Rasht, Iran, 2022. The demographic data, clinical characteristics, and consumption of complementary herbals were recorded. The mean age of the patients was 40 years, and 63.6% were female. The majority of the patients were educated. About 55.9% of patients consumed at least one herbal product, and the most consumed herbal product was mint extract. Most patients purchased herbal products from the grocery (93.1%); none referred to the pharmacy. About 89.2% of the patients recovered completely, and 10.8% had a disease recurrence. No particular complications were observed in most patients (97.7%). However, no significant association between the consumption of herbal products and patients' recovery was reported (P>0.05). According to our results, consuming herbal products results in no specific improvement in patients with H. pylori infection.

References

1. Choi IJ, Kim CG, Lee JY, Kim YI, Kook MC, Park B, et al. Family History of Gastric Cancer and Helicobacter pylori Treatment. N Engl J Med. 2020;382(5):427-36. DOI: 10.1056/NEJMoa1909666 PMID: 31995688

2. Salvatori S, Marafini I, Laudisi F, Monteleone G, Stolfi C. Helicobacter pylori and Gastric Cancer: Pathogenetic Mechanisms. Int J Mol Sci. 2023;24(3). DOI: 10.3390/ijms24032895 PMID: 36769214

3. Movahedi M, Afsharfard A, Moradi A, Nasermoaddeli A, Khoshnevis J, Fattahi F, et al. Survival rate of gastric cancer in Iran. J Res Med Sci. 2009;14(6):367-73. PMID: 21772910

4. Mladenova I. Clinical Relevance of Helicobacter pylori Infection. J Clin Med. 2021;10(16). DOI: 10.3390/jcm10163473 PMID: 34441769

5. Salih BA. Helicobacter pylori infection in developing countries: the burden for how long? Saudi J Gastroenterol. 2009;15(3):201-7. DOI: 10.4103/1319-3767.54743 PMID: 19636185

6. Farrell S, Doherty GM, Milliken I, Shield MD, McCallion WA. Risk factors for Helicobacter pylori infection in children: an examination of the role played by intrafamilial bed sharing. Pediatr Infect Dis J. 2005;24(2):149-52. DOI: 10.1097/01.inf.0000151104.14058.70 PMID: 15702044

7. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000;22(2):283-97. DOI: 10.1093/oxfordjournals.epirev.a018040 PMID: 11218379

8. Goodman KJ, Correa P, Tenganá Aux HJ, Ramírez H, DeLany JP, Guerrero Pepinosa O, et al. Helicobacter pylori infection in the Colombian Andes: a population-based study of transmission pathways. Am J Epidemiol. 1996;144(3):290-9. DOI: 10.1093/oxfordjournals.aje.a008924 PMID: 8686698

9. Pellicano R, Zagari RM, Zhang S, Saracco GM, Moss SF. Pharmacological considerations and step-by-step proposal for the treatment of Helicobacter pylori infection in the year 2018. Minerva Gastroenterol Dietol. 2018;64(3):310-21. DOI: 10.23736/S1121-421X.18.02492-3 PMID: 29600697

10. Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2017;112(2):212-39. DOI: 10.1038/ajg.2016.563 PMID: 28071659

11. Lin TF, Hsu PI. Second-line rescue treatment of Helicobacter pylori infection: Where are we now? World J Gastroenterol. 2018;24(40):4548-53. DOI: 10.3748/wjg.v24.i40.4548 PMID: 30386104

12. Puig I, López-Góngora S, Calvet X, Villoria A, Baylina M, Sanchez-Delgado J, et al. Systematic review: third-line susceptibility-guided treatment for Helicobacter pylori infection. Therap Adv Gastroenterol. 2016;9(4):437-48. DOI: 10.1177/1756283X15621229 PMID: 27366212

13. Vítor JM, Vale FF. Alternative therapies for Helicobacter pylori: probiotics and phytomedicine. FEMS Immunol Med Microbiol. 2011;63(2):153-64. DOI: 10.1111/j.1574-695X.2011.00865.x PMID: 22077218

14. Aliramaei MR, Rabbani khorasgani M, Rahmani MR, Zarkesh Esfahani SH. The effect of Iranian native medicinal plants on Helicobacter pylori: review study. J Microb Biol. 2019;8(31):1-18. [In Persian] DOI: 10.22108/bjm.2019.113830.1169

15. Ayala G, Escobedo-Hinojosa WI, de la Cruz-Herrera CF, Romero I. Exploring alternative treatments for Helicobacter pylori infection. World J Gastroenterol. 2014;20(6):1450-69. DOI: 10.3748/wjg.v20.i6.1450 PMID: 24587621

16. Akeel M, Elmakki E, Shehata A, Elhafey A, Aboshouk T, Ageely H, et al. Prevalence and factors associated with H. pylori infection in Saudi patients with dyspepsia. Electron Physician. 2018;10(9):7279-86. DOI: 10.19082/7279 PMID: 30258561

17. Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects. World J Gastroenterol. 2018;24(28):3071-89. DOI: 10.3748/wjg.v24.i28.3071 PMID: 30065554

18. Zamani M, Ebrahimtabar F, Zamani V, Miller WH, Alizadeh-Navaei R, Shokri-Shirvani J, et al. Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection. Aliment Pharmacol Ther. 2018;47(7):868-76. DOI: 10.1111/apt.14561 PMID: 29430669

19. Bastos J, Peleteiro B, Barros R, Alves L, Severo M, de Fátima Pina M, et al. Sociodemographic determinants of prevalence and incidence of Helicobacter pylori infection in Portuguese adults. Helicobacter. 2013;18(6):413-22. DOI: 10.1111/hel.12061 PMID: 23725608

20. Zamani M, Vahedi A, Maghdouri Z, Shokri-Shirvani J. Role of food in environmental transmission of Helicobacter pylori. Caspian J Intern Med. 2017;8(3):146-52. DOI: 10.22088/cjim.8.3.146 PMID: 28932364

21. Vale FF, Vítor JM. Transmission pathway of Helicobacter pylori: does food play a role in rural and urban areas? Int J Food Microbiol. 2010;138(1-2):1-12. DOI: 10.1016/j.ijfoodmicro.2010.01.016 PMID: 20122750

22. Nurgalieva ZZ, Malaty HM, Graham DY, Almuchambetova R, Machmudova A, Kapsultanova D, et al. Helicobacter pylori infection in Kazakhstan: effect of water source and household hygiene. Am J Trop Med Hyg. 2002;67(2):201-6. DOI: 10.4269/ajtmh.2002.67.201 PMID: 12389948

23. Asher GN, Corbett AH, Hawke RL. Common Herbal Dietary Supplement-Drug Interactions. Am Fam Physician. 2017;96(2):101-7. PMID: 28762712

24. Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, et al. Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol. 2010;16(3):207-14. DOI: 10.4103/1319-3767.65201 PMID: 20616418

25. Nir Y, Potasman I, Stermer E, Tabak M, Neeman I. Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter. 2000;5(2):94-7. DOI: 10.1046/j.1523-5378.2000.00014.x PMID: 10849058

26. Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002-2012. Natl Health Stat Report. 2015;(79):1-16. PMID: 25671660

27. Mishra LK, Sarkar D, Mentreddy R, Shetty K. Evaluation of phenolic bioactive-linked anti-hyperglycemic and Helicobacter pylori inhibitory activities of Asian Basil (Ocimum spp.) varieties. J Herb Med. 2020;20:100310. DOI: 10.1016/j.hermed.2019.100310

28. Ghannadi A, Sajjadi S-E, Abedi D, Yousefi J, Daraei-Ardekani R. The in vitro activity of seven Iranian plants of the Lamiaceae family against Helicobacter pylori. Niger J Nat Prod Med. 2004;8:40-2. DOI: 10.4314/njnpm.v8i1.11812

29. Laine L, Hunt R, El-Zimaity H, Nguyen B, Osato M, Spénard J. Bismuth-based quadruple therapy using a single capsule of bismuth biskalcitrate, metronidazole, and tetracycline given with omeprazole versus omeprazole, amoxicillin, and clarithromycin for eradication of Helicobacter pylori in duodenal ulcer patients: a prospective, randomized, multicenter, North American trial. Am J Gastroenterol. 2003;98(3):562-7. DOI: 10.1111/j.1572-0241.2003.t01-1-07288.x PMID: 12650788

30. Venerito M, Krieger T, Ecker T, Leandro G, Malfertheiner P. Meta-analysis of bismuth quadruple therapy versus clarithromycin triple therapy for empiric primary treatment of Helicobacter pylori infection. Digestion. 2013;88(1):33-45. DOI: 10.1159/000350719 PMID: 23880479

31. Dubois A, Borén T. Helicobacter pylori is invasive and it may be a facultative intracellular organism. Cell Microbiol. 2007;9(5):1108-16. DOI: 10.1111/j.1462-5822.2007.00921.x PMID: 17388791

32. Mégraud F. H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut. 2004;53(9):1374-84. DOI: 10.1136/gut.2003.022111 PMID: 15306603

33. Abachi S, Khademi F, Fatemi H, Malekzadeh F. Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori. IOSR J Dental Med Sci. 2013;5:155-9. URL: https://www.iosrjournals.org/iosr-jdms/papers/Vol5-issue1/O0515559.pdf

34. Moghaddam MN. In vitro inhibition of Helicobacter pylori by some spices and medicinal plants used in Iran. Glob J Pharmacol. 2011;5(3):176-80. URL: https://idosi.org/gjp/5(3)11/11.pdf

35. Murali MR, Naveen SV, Son CG, Raghavendran HRB. Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside. Integr Med Res. 2014;3(3):111-8. DOI: 10.1016/j.imr.2014.04.001 PMID: 28664086

Published

2024-03-30

Issue

Section

Original articles

How to Cite

Frequency of using complementary herbal medicines among Helicobacter pylori-infected patients in the North of Iran. (2024). Journal of Current Biomedical Reports, 5(1), 20-24. https://doi.org/10.61882/jcbior.5.1.245

Similar Articles

1-10 of 120

You may also start an advanced similarity search for this article.