Frequency of using complementary herbal medicines among Helicobacter pylori-infected patients in the North of Iran

Heydar Ali Balou, Mohammad Taghi Ashoobi, Hosnieh Kafshdar Jalali, Soheil Soltanipour, Sina Zare Jalise, Kourosh Delpasand

Abstract


Helicobacter pylori is a prevalent infection and one of the most critical factors that result in gastric cancer. Besides antibiotic therapy, some plants are suitable as an alternative treatment against H. pylori infection due to their role in protecting the gastric mucosa. This study investigated the frequency of using complementary herbal medicines among H. pylori-infected patients in the North of Iran. This cross-sectional study was conducted on 390 patients with H. pylori infection undergoing treatment in Rasht, Iran, 2022. The demographic data, clinical characteristics, and consumption of complementary herbals were recorded. The mean age of the patients was 40 years, and 63.6% were female. The majority of the patients were educated. About 55.9% of patients consumed at least one herbal product, and the most consumed herbal product was mint extract. Most patients purchased herbal products from the grocery (93.1%); none referred to the pharmacy. About 89.2% of the patients recovered completely, and 10.8% had a disease recurrence. No particular complications were observed in most patients (97.7%). However, no significant association between the consumption of herbal products and patients' recovery was reported (P>0.05). According to our results, consuming herbal products results in no specific improvement in patients with H. pylori infection.


Keywords


Helicobacter pylori; Gastric ulcer; Herbal medicine

Full Text:

Full-text PDF

References


Choi IJ, Kim CG, Lee JY, Kim YI, Kook MC, Park B, et al. Family History of Gastric Cancer and Helicobacter pylori Treatment. N Engl J Med. 2020; 382(5):427-36.

Salvatori S, Marafini I, Laudisi F, Monteleone G, Stolfi C. Helicobacter pylori and Gastric Cancer: Pathogenetic Mechanisms. Int J Mol Sci. 2023; 24(3).

Movahedi M, Afsharfard A, Moradi A, Nasermoaddeli A, Khoshnevis J, Fattahi F, et al. Survival rate of gastric cancer in Iran. J Res Med Sci. 2009; 14(6):367-73.

Mladenova I. Clinical Relevance of Helicobacter pylori Infection. J Clin Med. 2021; 10(16).

Salih BA. Helicobacter pylori infection in developing countries: the burden for how long? Saudi J Gastroenterol. 2009; 15(3):201-7.

Farrell S, Doherty GM, Milliken I, Shield MD, McCallion WA. Risk factors for Helicobacter pylori infection in children: an examination of the role played by intrafamilial bed sharing. Pediatr Infect Dis J. 2005; 24(2):149-52.

Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000; 22(2):283-97.

Goodman KJ, Correa P, Tenganá Aux HJ, Ramírez H, DeLany JP, Guerrero Pepinosa O, et al. Helicobacter pylori infection in the Colombian Andes: a population-based study of transmission pathways. Am J Epidemiol. 1996; 144(3):290-9.

Pellicano R, Zagari RM, Zhang S, Saracco GM, Moss SF. Pharmacological considerations and step-by-step proposal for the treatment of Helicobacter pylori infection in the year 2018. Minerva Gastroenterol Dietol. 2018; 64(3):310-21.

Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. Am J Gastroenterol. 2017; 112(2):212-39.

Lin TF, Hsu PI. Second-line rescue treatment of Helicobacter pylori infection: Where are we now? World J Gastroenterol. 2018; 24(40):4548-53.

Puig I, López-Góngora S, Calvet X, Villoria A, Baylina M, Sanchez-Delgado J, et al. Systematic review: third-line susceptibility-guided treatment for Helicobacter pylori infection. Therap Adv Gastroenterol. 2016; 9(4):437-48.

Vítor JM, Vale FF. Alternative therapies for Helicobacter pylori: probiotics and phytomedicine. FEMS Immunol Med Microbiol. 2011; 63(2):153-64.

Aliramaei MR, Rabbani khorasgani M, Rahmani MR, Zarkesh Esfahani SH. The effect of Iranian native medicinal plants on Helicobacter pylori: review study. J Microb Biol. 2019; 8(31):1-18.

Ayala G, Escobedo-Hinojosa WI, de la Cruz-Herrera CF, Romero I. Exploring alternative treatments for Helicobacter pylori infection. World J Gastroenterol. 2014; 20(6):1450-69.

Akeel M, Elmakki E, Shehata A, Elhafey A, Aboshouk T, Ageely H, et al. Prevalence and factors associated with H. pylori infection in Saudi patients with dyspepsia. Electron Physician. 2018; 10(9):7279-86.

Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects. World J Gastroenterol. 2018; 24(28):3071-89.

Zamani M, Ebrahimtabar F, Zamani V, Miller WH, Alizadeh-Navaei R, Shokri-Shirvani J, et al. Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection. Aliment Pharmacol Ther. 2018; 47(7):868-76.

Bastos J, Peleteiro B, Barros R, Alves L, Severo M, de Fátima Pina M, et al. Sociodemographic determinants of prevalence and incidence of Helicobacter pylori infection in Portuguese adults. Helicobacter. 2013; 18(6):413-22.

Zamani M, Vahedi A, Maghdouri Z, Shokri-Shirvani J. Role of food in environmental transmission of Helicobacter pylori. Caspian J Intern Med. 2017; 8(3):146-52.

Vale FF, Vítor JM. Transmission pathway of Helicobacter pylori: does food play a role in rural and urban areas? Int J Food Microbiol. 2010; 138(1-2):1-12.

Nurgalieva ZZ, Malaty HM, Graham DY, Almuchambetova R, Machmudova A, Kapsultanova D, et al. Helicobacter pylori infection in Kazakhstan: effect of water source and household hygiene. Am J Trop Med Hyg. 2002; 67(2):201-6.

Asher GN, Corbett AH, Hawke RL. Common Herbal Dietary Supplement-Drug Interactions. Am Fam Physician. 2017; 96(2):101-7.

Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, et al. Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol. 2010; 16(3):207-14.

Nir Y, Potasman I, Stermer E, Tabak M, Neeman I. Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter. 2000; 5(2):94-7.

Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL. Trends in the use of complementary health approaches among adults: United States, 2002-2012. Natl Health Stat Report. 2015; (79):1-16.

Mishra LK, Sarkar D, Mentreddy R, Shetty K. Evaluation of phenolic bioactive-linked anti-hyperglycemic and Helicobacter pylori inhibitory activities of Asian Basil (Ocimum spp.) varieties. J Herb Med. 2020; 20:100310.

Ghannadi A, Sajjadi S-E, Abedi D, Yousefi J, Daraei-Ardekani R. The in vitro activity of seven Iranian plants of the Lamiaceae family against Helicobacter pylori. Niger J Nat Prod Med. 2004; 8:40-2.

Laine L, Hunt R, El-Zimaity H, Nguyen B, Osato M, Spénard J. Bismuth-based quadruple therapy using a single capsule of bismuth biskalcitrate, metronidazole, and tetracycline given with omeprazole versus omeprazole, amoxicillin, and clarithromycin for eradication of Helicobacter pylori in duodenal ulcer patients: a prospective, randomized, multicenter, North American trial. Am J Gastroenterol. 2003; 98(3):562-7.

Venerito M, Krieger T, Ecker T, Leandro G, Malfertheiner P. Meta-analysis of bismuth quadruple therapy versus clarithromycin triple therapy for empiric primary treatment of Helicobacter pylori infection. Digestion. 2013; 88(1):33-45.

Dubois A, Borén T. Helicobacter pylori is invasive and it may be a facultative intracellular organism. Cell Microbiol. 2007; 9(5):1108-16.

Mégraud F. H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut. 2004; 53(9):1374-84.

Abachi S, Khademi F, Fatemi H, Malekzadeh F. Study of antibacterial activity of selected Iranian plant extracts on Helicobacter pylori. IOSR J Dental Med Sci. 2013; 5:155-9.

Moghaddam MN. In vitro inhibition of Helicobacter pylori by some spices and medicinal plants used in Iran. Glob J Pharmacol. 2011; 5(3):176-80.

Murali MR, Naveen SV, Son CG, Raghavendran HRB. Current knowledge on alleviating Helicobacter pylori infections through the use of some commonly known natural products: bench to bedside. Integr Med Res. 2014; 3(3):111-8.




DOI: https://doi.org/10.52547/JCBioR.5.1.245

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 © The Author(s)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.