Clinical Characteristics and symptoms of patients with the recurrence of COVID-19 and underlying disease in Taleghani and Valiasr hospitals in Khuzestan, Iran
Abstract
Background and aims: Due to the widespread prevalence of COVID-19 in the world, especially in Iran, this study attempted to evaluate risk factors associated with the recurrent of COVID-19 patients in health-care centers of Khuzestan province.
Methods: This study was conducted on patients admitted to Taleghani and Valiasr hospitals, with positive COVID-19 real-time-polymerase chain reaction (RT-PCR), from 20 February 2020 to 19 January 2021. Meanwhile, 398 cases with the recurrent of COVID-19 were included. Investigations were conducted as follows, demographic characteristics, clinical signs and symptoms, and underlying disease, history of ICU hospitalization, international travel, and contacts with foreign nationals and mortality. The collected data were recorded by laboratory experts.
Results: Out of 398 patients, 251 (63.07%) were male, and 147 (36.93%) were female. The average age was 49.39 years old. None of the patients were hospitalized in ICU. Most patients were in 30-40 years (24.37%). International travelling and contact with foreigners was observed in only 25 (6.28%) cases. The most underlying diseases were hypertension and diabetes. In this study, the number of patients who died was 253 (63.57%).
Conclusion: Due to the severe symptoms and higher mortality among COVID-19 recurrent patients with underlying disease, it is recommended to give more attention to COVID-19 recurrent patients with underlying diseases such as diabetes and hypertension. Presenting the results of this study to health-care systems might help a better understanding of risk-factors associated with the recurrent COVID-19 disease, leading to a better control and management of this patients.
Keywords: COVID-19, SARS-CoV-2, clinical characteristics, recurrence, Khuzestan, IranKeywords
References
Branson B, Tavakoli R, Khaledi M, Fathi J, Shafiee SM, Afkhami H, et al. The Correlations Between Epidemiological and Clinical Characteristics, laboratory tests and CT Scan reports in the diagnosis of cases 2019 novel coronavirus pneumonia. A Diagnostic Accuracy Study. Acta Medica Iranica. 2021:578-87.
Saberiyan M, Safi A, Kamel A, Movahhed-Abbasabad P, Miralimalek M, Afkhami H, et al. An Overview on the Common Laboratory Parameter Alterations and their Related Molecular Pathways in Screening for COVID-19 Patients. Clinical laboratory. 2020;66(10).
Organization WH. Coronavirus disease 2019 (COVID-19) situation report—97. World Health Organization, Geneva. 2020.
Sedighimehr N, Fathi J, Hadi N, Rezaeian ZS. Rehabilitation, a necessity in hospitalized and discharged people infected with COVID-19: a narrative review. Physical Therapy Reviews. 2021;26(3):202-10.
Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health. 2020;25(3):278-80.
Khaledi M, Yousefi Nojookambari N, Afkhami H, Sameni F, Yazdansetad S. A review on phylogenetic assessment and cytopathogenesis of filoviruses, retroviruses, and coronaviruses transmitted from bat to human. Journal of Cellular and Molecular Research (Iranian Journal of Biology). 2021.
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3.
Ojo AS, Balogun SA, Williams OT, Ojo OS. Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies. Pulm Med. 2020;2020:6175964.
Tezer H, Bedir Demirdag T. Novel coronavirus disease (COVID-19) in children. Turk J Med Sci. 2020;50(SI-1):592-603.
Fard NG, Khaledi M, Afkhami H, Barzan M, Farahani HE, Sameni F, et al. COVID-19 coinfection in patients with active tuberculosis: First case-report in Iran. Authorea Preprints. 2021.
Perrotta F, Corbi G, Mazzeo G, Boccia M, Aronne L, D'Agnano V, et al. COVID-19 and the elderly: insights into pathogenesis and clinical decision-making. Aging Clin Exp Res. 2020;32(8):1599-608.
Chen LK. Older adults and COVID-19 pandemic: Resilience matters. Arch Gerontol Geriatr. 2020;89:104124.
Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19. Emerg Microbes Infect. 2020;9(1):707-13.
Sankar J, Dhochak N, Kabra SK, Lodha R. COVID-19 in Children: Clinical Approach and Management. Indian J Pediatr. 2020;87(6):433-42.
Balasubramanian S, Rao NM, Goenka A, Roderick M, Ramanan AV. Coronavirus Disease 2019 (COVID-19) in Children - What We Know So Far and What We Do Not. Indian Pediatr. 2020;57(5):435-42.
Hamid Reza Samimagham 1 KS, Ali Daryanavard 1 , Mitra Kazemi Jahromi Recurrence of COVID-19 Infection. Shiraz E-Medical Journa. 2020.
Elzein F, Ibrahim A, Alshahrani F, Mahrous M, Murshid E, Aldhehyan T, et al. Reinfection, recurrence, or delayed presentation of COVID-19? Case series and review of the literature. Journal of infection and public health. 2021;14(4):474-7.
Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Persons for Coronavirus Disease 2019 (COVID-19). Center for Diseases Control and Prevention. 2020.
Jhuma Sankar ND, S. K. Kabra, Rakesh Lodha. COVID-19 in Children: Clinical Approach and Management. The Indian Journal of Pediatrics. 2020;87(6):433-42.
Organization WH. linical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance. . 2020.
Branson B, Tavakoli R, Khaledi M, Shafiee SM, Afkham H, Rastegar S. The Correlations Between Epidemiological and Clinical Characteristics, laboratory tests and CT Scan reports in the diagnosis of cases 2019 novel coronavirus pneumonia. A Diagnostic Accuracy Study. Authorea Preprints. 2021.
Abdullah M, Chai PS, Chong MY, Tohit ER, Ramasamy R, Pei CP, et al. Gender effect on in vitro lymphocyte subset levels of healthy individuals. Cell Immunol. 2012;272(2):214-9.
Marquez EJ, Chung CH, Marches R, Rossi RJ, Nehar-Belaid D, Eroglu A, et al. Sexual-dimorphism in human immune system aging. Nat Commun. 2020;11(1):751.
Spolarics Z, Pena G, Qin Y, Donnelly RJ, Livingston DH. Inherent X-Linked Genetic Variability and Cellular Mosaicism Unique to Females Contribute to Sex-Related Differences in the Innate Immune Response. Front Immunol. 2017;8:1455.
Laffont S, Rouquie N, Azar P, Seillet C, Plumas J, Aspord C, et al. X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-alpha production of plasmacytoid dendritic cells from women. J Immunol. 2014;193(11):5444-52.
Webb K, Peckham H, Radziszewska A, Menon M, Oliveri P, Simpson F, et al. Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration. Front Immunol. 2018;9:3167.
Qu K, Zaba LC, Giresi PG, Li R, Longmire M, Kim YH, et al. Individuality and variation of personal regulomes in primary human T cells. Cell Syst. 2015;1(1):51-61.
Wang J, Syrett CM, Kramer MC, Basu A, Atchison ML, Anguera MC. Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X. Proc Natl Acad Sci U S A. 2016;113(14):E2029-38.
Bukowska A, Spiller L, Wolke C, Lendeckel U, Weinert S, Hoffmann J, et al. Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men. Exp Biol Med (Maywood). 2017;242(14):1412-23.
Culebras E, Hernandez F. ACE2 is on the X chromosome: could this explain COVID-19 gender differences? Eur Heart J. 2020;41(32):3095.
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-9.
Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China. J Infect. 2020;80(4):388-93.
Monod M, Blenkinsop A, Xi X, Hebert D, Bershan S, Tietze S, et al. Age groups that sustain resurging COVID-19 epidemics in the United States. Science. 2021;371(6536).
Abdollah Abolfathi FM, Ashkan Lotfi Sheikhani , Gholam Reza Mirzaei , Azam Moslemi , Ruhollah Sohrabi. Demographic Characteristics, Clinical Symptoms, and Radiological Features in Patients With COVID-19 in Iran. JCCNC. 2020;6(3):163-74.
Yan Y, Yang Y, Wang F, Ren H, Zhang S, Shi X, et al. Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. BMJ Open Diabetes Res Care. 2020;8(1).
Shi Q, Zhang X, Jiang F, Zhang X, Hu N, Bimu C, et al. Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study. Diabetes Care. 2020;43(7):1382-91.
Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021;17(1):11-30.
Hosseinzadeh R, Goharrizi M, Bahardoust M, Alvanegh AG, Ataee MR, Bagheri M, et al. Should all patients with hypertension be worried about developing severe coronavirus disease 2019 (COVID-19)? Clin Hypertens. 2021;27(1):3.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Nasrin Ghodrati Fard, Sajedeh Sattarpour, Mojde Bagheri, Shahla Karami, Zahra Rafiei Atani, Fateme Rafiei Atani, Ahmad Sanaei, Fatemeh Maghsoudi, Sheida Mohammadi
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.