Metachronous occurrence of gastrointestinal stromal tumor and acute promyelocytic leukemia in a patient with ankylosing spondylitis: A case report

Authors

  • Fatemeh Nejatifar Department of Hematology and Oncology, Razi Clinical Research Development Unit, Guilan University of Medical Sciences, Rasht, Iran https://orcid.org/0000-0002-3858-8482
  • Habib Zayeni Department of Rheumatology, Guilan University of Medical Sciences, Rasht, Iran
  • Marjan Yaghmaie Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Narges Akrami Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

DOI:

https://doi.org/10.52547/jcbior.3.1.46

Keywords:

GIST, Acute promyelocytic leukemia, Ankylosing spondylitis, HLAB27

Abstract

Gastrointestinal stromal tumors are the most common mesenchymal tumor of the alimentary canal. Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia. A 57-year-old male patient with a previous record with history of gastrointestinal stromal tumors (GIST) and ankylosing spondylitis, was hospitalized with right ankle and foot swelling and pancytopenia. A diagnosis of APL was made by bone marrow aspiration and cytogenetic study. After a combined treatment with all-trans retinoic acid and arsenic trioxide, the patient achieved cytogenetic and molecular remission. According to past studies, the synchronous or metachronous coexistence of GISTs with other malignancies, such as lymphoma, liver cancer and pancreatic tumors has been widely reported. This study describes a patient with the metachronous occurrence of a CD34 positive GIST and APL. We suggest, the minor alterations in hematological parameters must be taken into consideration for such cases.

Downloads

Download data is not yet available.

References

Gao NA, Guo NJ, Yu WZ, Wang XX, Sun JR, Yu N, et al. Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature. Oncol Lett. 2016; 11(5):2977-80.

Hechtman JF, DeMatteo R, Nafa K, Chi P, Arcila ME, Dogan S, et al. Additional Primary Malignancies in Patients with Gastrointestinal Stromal Tumor (GIST): A Clinicopathologic Study of 260 Patients with Molecular Analysis and Review of the Literature. Ann Surg Oncol. 2015; 22(8):2633-9.

Kim HJ, Baek SK, Maeng CH, Kim SY, Park TS, Han JJ. Acute myeloid leukemia with t(11;19)(q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy: A case report. World J Clin Cases. 2020; 8(7):1251-6.

Ranatunga S, Miller AV. Active axial spondyloarthritis: potential role of certolizumab pegol. Ther Clin Risk Manag. 2014; 10:87-94.

Sanz MA, Lo Coco F, Martín G, Avvisati G, Rayón C, Barbui T, et al. Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups. Blood. 2000; 96(4):1247-53.

Joo YB, Choi SH, Kim SK, Shim B, Kim MS, Kim YJ. Synchronous development of KIT positive acute myeloid leukemia in a patient with gastrointestinal stromal tumor. Korean J Hematol. 2010; 45(1):66-9.

Miettinen M, Kraszewska E, Sobin LH, Lasota J. A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia. Cancer. 2008; 112(3):645-9.

Yu YP, Song P, Mei JG, An ZM, Zhou XG, Li F, et al. [Acute Promyelocytic Leukemia Developed during Imatinib Therapy for Gastrointestinal Stromal Tumors]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017; 25(2):358-64.

Miettinen M, Lasota J. Histopathology of gastrointestinal stromal tumor. J Surg Oncol. 2011; 104(8):865-73.

Muroi K, Nakamura M, Amemiya Y, Suda T, Miura Y. Expression of c-kit receptor (CD117) and CD34 in leukemic cells. Leuk Lymphoma. 1995; 16(3-4):297-305.

Wick RR, Nekolla EA, Gaubitz M, Schulte TL. Increased risk of myeloid leukaemia in patients with ankylosing spondylitis following treatment with radium-224. Rheumatology (Oxford). 2008; 47(6):855-9.

Published

2022-03-30

Issue

Section

Case reports

How to Cite

Metachronous occurrence of gastrointestinal stromal tumor and acute promyelocytic leukemia in a patient with ankylosing spondylitis: A case report. (2022). Journal of Current Biomedical Reports, 3(1), 46-49. https://doi.org/10.52547/jcbior.3.1.46

Similar Articles

1-10 of 22

You may also start an advanced similarity search for this article.