Impact of hepatitis B and C virus on chronic spontaneous urticaria; potential pathogenic triggers and aggravating factors

Abolfazl  Jafari-Sales; Shabnam  Khakpour-Ziaei; Safa  Meskini-Marandi; Mehrdad Pashazadeh

doi:10.61882/jcbior.6.1.302

Authors

Abolfazl Jafari-Sales 1. Department of Microbiology, Kaz.C., Islamic Azad University, Kazerun, Iran 2. Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran https://orcid.org/0000-0002-5710-4076
Shabnam Khakpour-Ziaei 2. Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran 3. Department of Cellular and Molecular Biology, Ta.C., Islamic Azad University, Tabriz, Iran https://orcid.org/0009-0002-1462-4079
Safa Meskini-Marandi 2. Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran 3. Department of Cellular and Molecular Biology, Ta.C., Islamic Azad University, Tabriz, Iran https://orcid.org/0009-0003-3670-0121
Mehrdad Pashazadeh 2. Infectious Diseases Research Center, TaMS.C., Islamic Azad University, Tabriz, Iran 4. Department of Medical Laboratory Sciences and Microbiology, TaMS.C., Islamic Azad University, Tabriz, Iran https://orcid.org/0000-0001-9103-6276

DOI:

https://doi.org/10.61882/jcbior.6.1.302

Keywords:

Urticaria, Chronic urticaria, Hepatitis viruses

Abstract

Chronic urticaria (CU) is a common dermatological condition characterized by persistent wheals lasting more than six weeks. Chronic spontaneous urticaria (CSU), the most prevalent CU subtype, significantly impairs patients' quality of life. Although its precise pathogenesis remains unclear, current evidence implicates multiple factors including immune dysregulation, stress, certain medications, and viral infections in its development and exacerbation. Among infectious triggers, hepatitis B (HBV) and C (HCV) viruses have emerged as potential CSU inducers. These viruses may trigger urticarial symptoms through various mechanisms, particularly immune system activation and cutaneous inflammatory responses. While the exact pathogenic pathways require further elucidation, clinical evidence suggests antiviral therapy may occasionally improve urticarial symptoms. Standard management of virus-associated CSU involves second-generation antihistamines as first-line treatment. For refractory cases, targeted therapies like omalizumab may be considered. Notably, successful HCV eradication has in some cases led to significant CSU improvement, an effect less frequently observed with HBV treatment. This study investigates the association between hepatitis infections and CSU, focusing particularly on elucidating how HBV and HCV could contribute to CSU pathogenesis.

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